New Sterile Filtration Challenges in the Changing Landscape of Drug Formulations
Drug formulations are changing! Development of new, complex drug formulations has given us therapeutics with properties that are markedly different from traditional drug types. This paper discusses the...
View ArticleValidation of a Next-Generation Single-Use Turbidity System
Turbidity describes the relative clarity of a liquid as the result of suspended solids. Instruments that measure turbidity typically use a beam of light to detect particles by measuring the difference...
View ArticleThe Effect of Benzonase Endonuclease Addition to Purification of Sabin...
During production of vaccines and viral vectors, the size and quantity of extracellular nucleic acids must be reduced using endonuclease enzymes. Merck/MilliporeSigma’s proprietary Benzonase...
View ArticleComparing Single-Use Multicycle Cake Filtration with Depth Filtration:...
Over the past few decades, single-use (SU) technology has increased bioproduction efficiency significantly, especially with the introduction of disposable bioreactors in upstream processing. To keep...
View ArticleReducing Downstream Scale-Up Needs: Advances Toward Continuous Downstream...
The biopharmaceutical industry generally acknowledges that upstream and downstream aspects of drug-substance manufacturing are experiencing a capacity mismatch. Today, many recombinant proteins can be...
View ArticleThe Impact of Protein Stability on Virus Filtration
Filtration of protein-based biologics is essential for minimizing viral contamination and ensuring product safety and high quality. The tendency of therapeutic monoclonal antibodies (MAbs) and...
View ArticleUsing 3D Imaging To Understand Sterilizing-Grade Filtration of Liposomes
Sterilizing-grade filtration is an essential operation for biomanufacturing. It ensures that drug substances are free from microorganisms at the end of a downstream process. The COVID-19 pandemic has...
View ArticleTangential-Flow Filtration Process Control and Data Acquisition System for...
PendoTECH tangential-flow filtration (TFF) process control systems have been widely adopted in the filtration community. The system’s features enable its implementation in multiple unit operations and...
View ArticleHollow-Fiber Nanofiltration for Robust Viral Clearance of Non-MAb Biologics
Monoclonal antibody (MAb) and other therapeutic biologics produced by mammalian cells have the potential to introduce endogenous retroviruses and can be infected with adventitious viruses through raw...
View ArticleSave Valuable Facility Time with Single-Use TFF
Biopharmaceutical developers and manufacturers are part of a global, dynamic, and highly competitive market. They face constant pressure to produce high-quality products within relatively short time...
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